| Autor: |
Qian, Xiao, Zhi-Ping, Zhang, Yang-Bo, Hou, Dong-Xiao, Qu, Le-Le, Tang, Li-Ji, Chen, Guo-Yi, Li, Yong-Hua, Ji, Jie, Tao, Yu-Dan, Zhu |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Sheng li xue bao : [Acta physiologica Sinica]. 74(4) |
| ISSN: |
0371-0874 |
| Popis: |
The East Asian scorpion Buthus martensii Karsch (BmK) is one of the classical traditional Chinese medicines for treating epilepsy for over a thousand years. Neurotoxins purified from BmK venom are considered as the main active ingredients, acting on membrane ion channels. Voltage-gated sodium channels (VGSCs) play a crucial role in the occurrence of epilepsy, which make them become important drug targets for epilepsy. Long chain toxins of BmK, composed of 60-70 amino acid residues, could specifically recognize VGSCs. Among them, α-like neurotoxins, binding to the receptor site-3 of VGSC, induce epilepsy in rodents and can be used to establish seizure models. The β or β-like neurotoxins, binding to the receptor site-4 of VGSC, have significant anticonvulsant effects in epileptic models. This review aims to illuminate the anticonvulsant/convulsant effects of BmK polypeptides by acting on VGSCs, and provide potential frameworks for the anti-epileptic drug-design. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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