Organocatalytic sequential alpha-amination-Horner-Wadsworth-Emmons olefination of aldehydes: enantioselective synthesis of gamma-amino-alpha,beta-unsaturated esters

Autor:	Shriram P, Kotkar, Vilas B, Chavan, Arumugam, Sudalai
Rok vydání:	2007
Předmět:	Aldehydes Alkaloids Molecular Structure Cyclization Combinatorial Chemistry Techniques Esters Stereoisomerism Alkenes Amines Catalysis Pyrrolidinones
Zdroj:	Organic letters. 9(6)
ISSN:	1523-7060
Popis:	A novel and highly enantioselective method for the synthesis of gamma-amino-alpha,beta-unsaturated esters via tandem alpha-amination-Horner-Wadsworth-Emmons (HWE) olefination of aldehydes is described. The one-pot assembly has been demonstrated for the construction of functionalized chiral 2-pyrrolidones, subunits present in several alkaloids. [structure: see text]
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::827e2b3bb4da09cd8427b3a4780b03cb https://pubmed.ncbi.nlm.nih.gov/17295495 Zobrazit plný text záznamu