Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis: diagnosis by polymerase chain reaction

Autor:	C E, Oyer, E H, Ongcapin, J, Ni, N E, Bowles, J A, Towbin
Rok vydání:	2000
Předmět:	Adult Male Adenoviridae Infections Adenoviruses Human Hydrops Fetalis Myocardium Infant Newborn Calcinosis Aortic Valve Stenosis Fibrosis Polymerase Chain Reaction Ultrasonography Prenatal Pulmonary Valve Stenosis Myocarditis Pregnancy Aortic Valve DNA Viral Humans Female
Zdroj:	Human pathology. 31(11)
ISSN:	0046-8177
Popis:	We report a case of fatal hydrops fetalis owing to adenoviral endomyocarditis with aortic and pulmonary valve stenosis. A 1850-g macerated male stillborn delivered 1 week after fetal ultrasonography showed hydrops, cardiomegaly, and possible aortic valve stenosis. Autopsy confirmed hydrops and showed thickened, fibrotic semilunar valves with stenosis. The myocardium was focally fibrotic with areas of calcification. Polymerase chain reaction study of myocardial and aortic valve tissue was positive for adenovirus. Intrauterine viral myocarditis has been reported only rarely, but cases owing to Coxsackie B virus, adenovirus, and parvovirus B19 have appeared in the literature. With the exception of rubella, viral causation of significant valvular lesions in humans has received scanty support in the literature. This report suggests a broader group of causative agents. HUM PATHOL 31:1433-1435.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::821f3157e1a3456bfe1a000a1adf0862 https://pubmed.ncbi.nlm.nih.gov/11112222 Zobrazit plný text záznamu Full Text from ScienceDirect