A randomized trial regarding antimicrobial prophylaxis (AMP) in transurethral resection of bladder tumor (TURB)

Autor:	E, Baten, F, Van der Aa, H, Goethuys, K, Slabbert, I, Arijs, K, van Renterghem
Rok vydání:	2021
Předmět:	Aged 80 and over Male Carcinoma Transitional Cell Fever Cystoscopy Levofloxacin Antibiotic Prophylaxis Anti-Bacterial Agents Logistic Models Postoperative Complications Urinary Bladder Neoplasms Ciprofloxacin Cefazolin Urinary Tract Infections Humans Surgical Wound Infection Female Amikacin Aged
Zdroj:	World journal of urology. 39(10)
ISSN:	1433-8726
Popis:	To determine whether omitting antimicrobial prophylaxis (AMP) in TURB is safe in patients undergoing TURB without an indwelling pre-operative catheter/nephrostomy/DJ and a negative pre-operative urinary culture.A multi-centered randomized controlled trial (RCT) from 17-09-2017 to 31-12-2019 in 5 hospitals. Patients with a pre-operative indwelling catheter/DJ-stent or nephrostomy and a positive pre-operative urinary culture ( 10459 Patients were included and 202/459 (44.1%) received AMP vs 257/459 (55.9%) without AMP. Fever occurred in 6/202 [2.9%; 95% CI (1.2-6.6%)] patients with AMP vs 8/257 [3.1%; 95% CI (1.5%-6.1%)] without AMP (p = 0.44). Multivariable, logistic regression showed no significant harm in omitting AMP when controlled for (clot-)retention and tumor size (p = 0.85) and an adjusted risk difference in developing post-TURB fever of 0.0016; 95% CI [- 0.029; 0.032].Our data suggest the safety of omitting AMP in patients undergoing TURB without an indwelling, pre-operative catheter/nephrostomy/DJ and a negative pre-operative urinary culture.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::82050559da6b0981f9a49d85895d7d3d https://pubmed.ncbi.nlm.nih.gov/33839918 Zobrazit plný text záznamu Full text from SpringerLink