| Autor: |
D X, Wang, G S, Lu, W, Liu, N G, Wang, M Z, Guan, Y L, Zhao, X N, Wang, Z P, Cheng |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Yao xue xue bao = Acta pharmaceutica Sinica. 26(1) |
| ISSN: |
0513-4870 |
| Popis: |
Eleven peptides containing hydroxy-amino-acid have been synthesized manually by stepwise solid-phase method. Three of them were started on BHA-resin, the others on Merrifield-resin. TFMSA/TFA/p-cresol were used as cleaving reagent in all peptide-resin (1-11) cleavage. Furthermore, HF cleaving procedure was also used parallelly to five of those peptide-resins for contrast. No conspicuous difference in yield was found between TFMSA and HF. The purity of all products was checked by the profiles of analytical reversed phase HPLC (C-18) and the data of amino acid analysis. All synthetic peptides were tested for the effect on progesterone production by rat corpus luteum in vitro. Among them, three peptides, GlyTyr-NH2, LysTyr-NH2 and GlySer Lys-OH, showed significant effect (p less than 0.01) on inhibiting hCG-induced progesterone production. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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