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24-hour Holter monitoring was performed in 58 patients with stable angina pectoris. Out of them, 70.7% were recorded to have painless ischemic ST-segment depression episodes which made up some half (45.7%) of the total number of myocardial ischemic episodes. The episodes of silent myocardial ischemia were characterized by various length, depending on the conditions of their occurrence. They were far short-term with physical activity and long-term at rest. An increase in the number of diseased coronary vessels in the patients undergoing coronary angiography was followed by a rise in the amount of episodes and ST-segment displacement amplitude. In patients who had an bicycle ergometric loading of 100 Wt or greater, the episodes of silent myocardial ischemia were observed twice more frequently than in patients who had a threshold loading of 25 to 50 Wt. Some proportion of the patients exhibited variations in the Holter monitoring and paired bicycle ergometric tests when finoptin and obsidan were evaluated for their antianginal effect. There was a significant decrease in obsidan's effect following 2-month continuous therapy. Despite the persistent growth of exercise tolerance as evidenced by bicycle ergometry, finoptin proved to be inefficient in 46.2% of the patients. |
