Progression from amnesic mild cognitive impairment to Alzheimer's disease: ESR1 and ESR2 polymorphisms and APOE gene
| Autor: | X, Elcoroaristizabal Martín, M, Fernández Martínez, L, Galdos Alcelay, A, Molano Salazar, R, Bereincua Gandarias, S, Inglés Borda, F, Gómez Busto, J M, Uterga Valiente, B, Indakoetxea Juanbeltz, M A, Gómez Beldarraín, M M, de Pancorbo |
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| Rok vydání: | 2011 |
| Předmět: |
Aged
80 and over Male Polymorphism Genetic Genotype Apolipoprotein E4 Estrogen Receptor alpha Middle Aged Neuropsychological Tests Polymorphism Single Nucleotide Apolipoproteins E Gene Frequency Alzheimer Disease Risk Factors Disease Progression Estrogen Receptor beta Humans Cognitive Dysfunction Female Genetic Predisposition to Disease Longitudinal Studies Alleles Aged Proportional Hazards Models |
| Zdroj: | Dementia and geriatric cognitive disorders. 32(5) |
| ISSN: | 1421-9824 |
| Popis: | Many genes have been studied to determine how they might be involved in Alzheimer's disease (AD). Estrogens have a protective effect in the central nervous system. The mechanisms of action of estrogens are mediated by two estrogen receptors (ERs), ERα and ERβ. Thus, these genes could also play a role in the progression of amnesic mild cognitive impairment (MCIa) to AD. The aim of this study was to examine the role of ER single nucleotide polymorphisms (SNPs) as a risk factor for MCIa, as well as the interaction with apolipoprotein E (APOE) ε4 in the progression to AD.79 MCIa patients and 138 healthy controls were analyzed. SNPs were genotyped via restriction fragment length polymorphisms and real-time PCR, RT-PCR or RT-PCR (TaqMan) assays.There is a lack of association between MCIa patients who converted to AD and ER SNPs. APOE ε4 allele is an independent risk factor of MCIa (OR=1.86; 95% CI=1.02-3.38, p=0.042) with a high prevalence in converted subjects. APOE ε4 is able to predict the progression from MCIa patients to AD (OR=2.55; 95% CI=1.20-5.42, p=0.015).The presence of the APOE ε4 allele, and not the alleles of ER SNPs, is a risk factor for MCIa. Furthermore, APOE genotype seems to predict the conversion from MCIa to AD. |
| Databáze: | OpenAIRE |
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