| Autor: |
Jennifer L, Holness, Anita, Brink, M Razeen, Davids, James M, Warwick |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Pediatric nephrology (Berlin, Germany). 36(3) |
| ISSN: |
1432-198X |
| Popis: |
Creatinine-based glomerular filtration rate (GFR)-estimating equations frequently do not perform well in populations that differ from the development populations in terms of mean GFR, age, pathology, ethnicity, and diet. After first evaluating the performance of existing equations, the aim of this study was to demonstrate the utility of an in-house modification of the equations to better fit a specific population.Estimated GFR using 8 creatinine-based equations was first compared to 2-sampleTwo hundred fifty-six GFR measurements were performed in 160 children. GFR was overestimated in both groups (non-cancer 4.3-22.6 ml/min/1.73 mModifying the parameters of pediatric GFR estimating-equations using a simple Excel-based tool significantly improved their accuracy in both non-cancer and cancer populations. Graphical abstract. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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