[Effects of midodrine on symptomatic hypotension during hemodialysis]

Autor: Alejandro, Cotera, Miriam, Alvo, María Eugenia, Sanhueza, Leticia, Elgueta, Juan Pablo, Gormaz, Carlos, Ibáñez, Cristián, Cuadra
Rok vydání: 2002
Předmět:
Zdroj: Revista medica de Chile. 130(9)
ISSN: 0034-9887
Popis: Hypotension occurs in 20% of hemodialysis procedures.To study the effects of midodrine on hypotension during hemodialysis.Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design.Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3 +/- 28 mmHg with midodrine and 23.4 +/- 28 mmHg with placebo. Diastolic blood pressure fell 7.3 +/- 11.5 mmHg with midodrine and 11.1 +/- 12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine.Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension.
Databáze: OpenAIRE