Cerebrovascular injuries induced by activation of platelets and leukocytes in vivo and their correction by neurotropin

Autor:	E S, Gabrielian, S E, Akopov, M R, Grigorian, K S, Toumasian
Rok vydání:	1992
Předmět:	Blood Platelets Platelet Aggregation Neutrophils Platelet Count Brain Edema Cerebrovascular Disorders Leukocyte Count Carotid Arteries Injections Intra-Arterial Polysaccharides Parietal Lobe Cats Animals Tetradecanoylphorbol Acetate Cell Aggregation
Zdroj:	Japanese journal of pharmacology. 60(1)
ISSN:	0021-5198
Popis:	Ischemia-like brain damage was induced in cats by selective injection of 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA) into the left carotid artery. PMA-injection provoked significant decreases in platelet and neutrophil counts due to their intravascular aggregation. Platelet and neutrophil aggregates caused brain edema with accumulation of sodium fluorescein in the cerebrospinal fluid and ipsilateral derangement of the cerebral energy state in the parietal cortex. Neurotropin administration decreased the changes in platelet and neutrophil counts and prevented the developments of both brain edema and cerebral energy failure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8195be6edacdb6b861847ce5b342db1d https://pubmed.ncbi.nlm.nih.gov/1460805 Zobrazit plný text záznamu