Postnatal development of mixed-function oxidation as measured in microsomes from the small intestine and liver of rabbits
| Autor: | J M, Tredger, R S, Chhabra, J R, Fouts |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Aging Aniline Hydroxylase Mixed Function Oxygenases Cytochrome P-450 Enzyme System Liver Organ Specificity Microsomes Intestine Small Microsomes Liver Animals Female Aryl Hydrocarbon Hydroxylases Rabbits Oxidoreductases Benzopyrene Hydroxylase Aminopyrine N-Demethylase NADPH-Ferrihemoprotein Reductase |
| Zdroj: | Drug metabolism and disposition: the biological fate of chemicals. 4(1) |
| ISSN: | 0090-9556 |
| Popis: | The postnatal development of aminopyrine N-demethylase, aniline 4-hydroxylase, benzpyrene hydroxylase, biphenyl 4-hydroxylase, 7-ethoxycoumarin 0-deethylase activities, NADPH-cytochrome c reductase, and cytochrome P-450 was compared in microsomes from the liver and small intestine of New Zealand white rabbits. Apart from hepatic aniline hydroxylase activity, all of the xenobiotic-metabolizing enzyme activities examined had a similar pattern of development in the liver and small intestine. In both tissues the ability to metabolize xenobiotics was generally undetectable at 2 days of age and remained relatively low for the first 20 days of life. Theresfter, a rapid 2- to 5-fold increase in all the enzyme activity studied was noted, and adult values were reached or exceeded by 30 days of age. Subsequent development of xenobiotic-metabolizing enzyme activities in the small intestine, but not in the liver, exhibited a transient fall at 50 days of age before adult activities were attained after 75 days of age. The developmental pattern of cytochrome P-450 in the small intestine closely resembled that of the xenobiotic-metabolizing enzyme activities, but in the liver this correlation was less exact. |
| Databáze: | OpenAIRE |
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