| Autor: |
Matteo, Pollastrini, Filippo, Lipparini, Luca, Pasquinelli, Federica, Balzano, Gloria Uccello, Barretta, Gennaro, Pescitelli, Gaetano, Angelici |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
The Journal of Organic Chemistry |
| ISSN: |
1520-6904 |
| Popis: |
A thorough experimental and computational study on the conformational properties of (S)-indoline-2-carboxylic acid derivatives has been conducted. Methyl (S)-1-acetylindoline-2-carboxylate, both a mimetic of proline and phenylalanine, shows a remarkable tendency toward the cis amide isomer when dissolved in polar solvents. This behavior is opposite to the general preference of proline for the trans isomer, making indoline-2-carboxylic acid a good candidate for the design of different secondary structures and new materials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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