| Autor: |
Tania, Barth, Aline, Silva, Simone Setubal, Dos Santos, Jane Lima, Santos, Patrícia Diniz, Andrade, Jessica, Tsai, Eloísa Dutra, Caldas, Mariana de Souza, Castro, Osmindo Rodrigues, Pires |
| Rok vydání: |
2021 |
| Zdroj: |
The journal of venomous animals and toxins including tropical diseases. 28 |
| ISSN: |
1678-9199 |
| Popis: |
Acylpolyamines are one of the main non-peptide compounds present in spider venom and represent a promising alternative in the search for new molecules with antimicrobial action.The venom ofFive acylpolyamines were isolated from the venom with molecular masses between 614 Da and 756 Da, being named ApAn728, ApAn614a, ApAn614b, ApAn742 and ApAn756. The analysis of UV absorption profile of each ApAn and the fragmentation pattern obtained by ESI-MS/MS suggested the presence of a tyrosyl unit as chromophore and a terminal polyamine chain consistent with structural units PA43 or PA53. ApAn presented MIC between 128 µM and 256 µM againstThe antimicrobial and non-hemolytic properties of the analyzed ApAn may be relevant for their application as possible therapeutic agents and the identification of an unconventional chromophore for spider acylpolyamines suggests an even greater chemical diversity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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