| Autor: |
Tong-Jing, Xing, Kang-Xian, Luo, Jin-Lin, Hou |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. 22(6) |
| ISSN: |
1000-2588 |
| Popis: |
To screen the differential points related with response to interferon-alpha in HBV post-transcriptional regulatory element (HPRE).HPRE sequence of 31 Chinese patients with HBV infection were detected by direct sequencing of PCR products. Differential points in HPRE between Chinese patients and White patients were compared.The T to C differential point at nt 1 504 and C to T(G) at nt 1 508 were found respectively in HPRE of 21 and 19 patients with chronic hepatitis B, the C to T differential point at nt 1 509 were found in 17 cases. These differential points were not found in HPRE of the White patients. The relationship between the HPRE differential points and the levels of HBV DNA was not observed.There were differential points in the HPRE between Chinese and White HBV patients, which might be correlated with response to interferon-alpha. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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