Nodal metastasis and survival in oral cancer: Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2
| Autor: | Rob, Noorlag, Petra, van der Groep, Frank K J, Leusink, Sander R, van Hooff, Michaël H, Frank, Stefan M, Willems, Robert J J, van Es |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Kaplan-Meier Estimate Sensitivity and Specificity Lipocalin-2 Antigens Neoplasm Predictive Value of Tests Proto-Oncogene Proteins Biomarkers Tumor Humans Secretory Leukocyte Peptidase Inhibitor Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over Gene Expression Profiling Middle Aged Lipocalins Lymphatic Metastasis Carcinoma Squamous Cell Lymph Node Excision Female Mouth Neoplasms Thrombospondins Cell Adhesion Molecules Acute-Phase Proteins |
| Zdroj: | Headneck. 37(8) |
| ISSN: | 1097-0347 |
| Popis: | Gene expression profiling revealed a strong signature predicting lymph node metastases in oral squamous cell carcinoma (OSCC). Four of the most predictive genes are secretory leukocyte protease inhibitor (SLPI), lipocalin-2 (LCN2), thrombospondin-2 (THBS2), and tumor-associated calcium signal transducer 2 (TACSTD2). This study correlates their protein expression with lymph node metastases, overall survival (OS), and disease-specific survival (DSS).Two hundred twelve patients with OSCC were included for protein expression analysis by immunohistochemistry.SLPI expression correlates with lymph node metastases in the whole cohort, not in a subgroup of cT1 to 2N0. SLPI expression correlates with OS (hazard ratio [HR] = 0.61) and DSS (HR = 0.47) in multivariate analysis. LCN2, THBS2, and TACSTD2 show no correlation with lymph node metastases, OS, or DSS.Although SLPI expression correlates with lymph node metastases, it has no additional value in determining lymph node metastases in early oral cancer. However, it is an independent predictor for both OS and DSS and therefore a relevant prognostic biomarker in OSCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text