Coinfection with herpesviruses in young children of HIV-infected women
| Autor: | J L, Sever, T A, Rakusan, M, Ellaurie, N, Frenkel, L S, Wyatt, J M, Campos, R M, O'Donnell, M V, Price |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Herpesvirus 4 Human Herpesvirus 6 Human Cytomegalovirus Infant HIV Infections Herpesvirus 7 Human Herpesviridae Infections Antibodies Viral Infectious Disease Transmission Vertical CD4 Lymphocyte Count Immunoglobulin M Pregnancy Case-Control Studies Child Preschool HIV Seronegativity HIV Seropositivity Humans Female Pregnancy Complications Infectious |
| Zdroj: | Pediatric AIDS and HIV infection. 6(2) |
| ISSN: | 1045-5418 |
| Popis: | Coinfection with herpesviruses in young children born to human immunodeficiency virus (HIV)-infected women was studied with blood samples from children who were 9-12 months and 15-24 months of age. Three groups of children were included: (I) HIV-uninfected, asymptomatic (HIV-); (II) polymerase chain reaction (PCR) and/or culture-positive and asymptomatic or mildly symptomatic (HIV+ asymptomatic); and (III) PCR and/or culture-positive and symptomatic (HIV+ symptomatic). Significantly more of the HIV+ symptomatic patients had cytomegalovirus (CMV) antibody than the HIV patients. In addition, CMV antibody levels were significantly higher in the HIV+ symptomatic patients than in either of the other two groups. Human herpesvirus 7 (HHV-7) antibody titers were significantly different among the three groups of patients; however, no pairwise comparisons were significant. No differences were found for HHV-6 or Epstein-Barr virus (EBV) antibody frequencies or titers. These findings suggest that infection with CMV is a cofactor or an opportunistic infection causing symptomatic HIV infections in young children. |
| Databáze: | OpenAIRE |
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