Evaluation of the prethrombotic state in pregnancy and in women using oral contraceptives

Autor:	A B, Levine, J, Teppa, B, McGough, F S, Cowchock
Rok vydání:	1996
Předmět:	Time Factors Pregnancy Antithrombin III Humans Female Prothrombin Thrombosis Peptide Fragments Contraceptives Oral Peptide Hydrolases
Zdroj:	Contraception. 53(5)
ISSN:	0010-7824
Popis:	The purpose of this study was to determine the effects of pregnancy and oral contraceptive use on in vivo coagulation by measurement of plasma levels of prothrombin fragment 1 + 2 and thrombin antithrombin III complex. Fifty-four women with uncomplicated singleton gestations, 34 women using oral contraceptives and 45 non-pregnant controls were the subjects of this study. Levels of prothrombin fragment 1 + 2 and thrombin-antithrombin III complex were measured using enzyme linked immunoassays. In uncomplicated pregnancies, levels of prothrombin fragment 1 + 2 and thrombin antithrombin III complex increased significantly with advancing gestational age. Women using oral contraceptives had significantly higher levels of prothrombin fragment 1 + 2 and thrombin antithrombin III complex compared to non-pregnant controls. The significant increase in levels of prothrombin fragment 1 + 2 and thrombin-antithrombin III complex throughout gestation and in women using oral contraceptives provided evidence of thrombin activation during these clinical conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8131d168184a589f6576a5f866a0c878 https://pubmed.ncbi.nlm.nih.gov/9013062 Zobrazit plný text záznamu Full Text from ScienceDirect