| Autor: |
Sensenig, Rachel, Kalghatgi, Sameer, Cerchar, Ekaterina, Fridman, Gregory, Shereshevsky, Alexey, Torabi, Behzad, Arjunan, Krishna Priya, Podolsky, Erica, Fridman, Alexander, Friedman, Gary, Azizkhan-Clifford, Jane, Brooks, Ari D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Popis: |
Non-thermal atmospheric pressure dielectric barrier discharge (DBD) plasma may provide a novel approach to treat malignancies via induction of apoptosis. The purpose of this study was to evaluate the potential of DBD plasma to induce apoptosis in melanoma cells. Melanoma cells were exposed to plasma at doses that did not induce necrosis, and cell viability and apoptotic activity were evaluated by Trypan blue exclusion test, Annexin-V/PI staining, caspase-3 cleavage, and TUNEL® analysis. Trypan blue staining revealed that non-thermal plasma treatment significantly decreased the viability of cells in a dose-dependent manner 3 and 24 h after plasma treatment. Annexin-V/PI staining revealed a significant increase in apoptosis in plasma-treated cells at 24, 48, and 72 h post-treatment (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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