Relative adrenal insufficiency in mice deficient in 5α-reductase 1
| Autor: | Dawn E W, Livingstone, Emma M, Di Rollo, Chenjing, Yang, Lucy E, Codrington, John A, Mathews, Madina, Kara, Katherine A, Hughes, Christopher J, Kenyon, Brian R, Walker, Ruth, Andrew |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Mice Knockout Hypothalamo-Hypophyseal System glucocorticoids Research 5α-reductases HPA axis Membrane Proteins Pituitary-Adrenal System Dexamethasone Mice 5-alpha Reductase Inhibitors 3-Oxo-5-alpha-Steroid 4-Dehydrogenase Adrenocorticotropic Hormone Animals Corticosterone adrenal insufficiency Stress Psychological |
| Zdroj: | The Journal of Endocrinology |
| ISSN: | 1479-6805 |
| Popis: | Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as ‘relative adrenal insufficiency’. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases type 1 and type 2 and 5β-reductase, resulting in compensatory downregulation of the hypothalamic–pituitary–adrenal axis and adrenocortical atrophy. To test the hypothesis that impaired glucocorticoid clearance can cause relative adrenal insufficiency, we investigated the consequences of 5α-reductase type 1 deficiency in mice. In adrenalectomised male mice with targeted disruption of 5α-reductase type 1, clearance of corticosterone was lower after acute or chronic (eightfold, P |
| Databáze: | OpenAIRE |
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