| Autor: |
Jared, Langerman, Sotirios G, Doukas, Hisashi, Hasegawa, James, Goodrich, Michael, Lerner, Clarence, Sasaki |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Laryngoscope Investigative Otolaryngology |
| ISSN: |
2378-8038 |
| Popis: |
Background A malfunction or impairment of swallow function can potentiate aspiration events and interfere with both quality of life and survival. Establishing an animal model for swallow research would provide a better understanding of its pathophysiology and would also allow for the development and validation of physiologically based clinical interventions to improve swallow function. Two requirements define the ideal model for longitudinal exploration: 1) identification of species similar to human in form and function; and 2) provision for reliable and reproducible evoked swallow under general anesthesia and one that would also support a longitudinal study design. Objective We hypothesize that an anesthetized porcine model under dexmedetomidine‐based or ketamine‐based anesthesia will support a reproducible and stable evoked swallow response. Methods Seven neutered male Yorkshire pigs were anesthetized using combinations of dexmedetomidine‐based or ketamine‐based anesthesia for induction and maintenance of anesthesia during the experimental portion of our study. Single stimulation of iSLN or vagus nerve, bilateral simultaneous single stimulation of iSLN or vagus nerve, and stimulus trains applied to afferent nerves were performed. Results None of the seven pigs demonstrated evoked swallow events, both during inhalational anesthesia (1.0 MAC) or during post‐washout intravenous anesthesia (dexmedetomidine, ketamine/fentanyl or ketamine alone). Conclusion Our results support a high degree of organizational neurophysiologic complexity characterizing the swallow reflex and highlight the challenges and limitations of intraoperative study in survival models. Level of Evidence NA Laryngoscope, 2018 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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