Celiac disease: 10-year experience in a Romanian tertiary center
| Autor: | Roxana, Maxim, Alina, Pleşa, Irina, Ciortescu, Irina, Gîrleanu, Oana, Stoica, Anca-Victoriţa, Trifan |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent Biopsy Risk Assessment Gliadin Body Mass Index GTP-Binding Proteins Risk Factors Prevalence Humans Immunologic Factors Protein Glutamine gamma Glutamyltransferase 2 Aged Retrospective Studies Academic Medical Centers Transglutaminases Romania Incidence Middle Aged Antibodies Anti-Idiotypic Immunoglobulin A Celiac Disease Female Algorithms Biomarkers |
| Zdroj: | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 118(4) |
| ISSN: | 0048-7848 |
| Popis: | To evaluate the experience of a single coeliac center over a 10-year-observational period.Between January 2003 and December 2013 a total of 195 consecutive patients admitted with celiac disease were tested by multiple duodenal biopsies, anti-tissue transglutaminase and anti-gliadin antibodies, and baseline demographic, clinical, biological and immunological parameters.Patients were divided into two major groups according to the clinical features and number of signs and symptoms present upon admission: gastrointestinal (131, 67.17%) and non-gastrointestinal (64, 32.8%). Anti-tissue transglutaminase and anti-gliadin antibodies showed seropositivity in 109/158. Histological samples were available in 152 cases, according to Marsh-Oberhuber classification 11.18% being type 0, 17.76%, type I-II, and 71.05% type III. Correlations between anti-tissue transglutaminase antibody titers and Marsh-Oberhuber classification were found to be statistically significant. Body mass index was available in 96 cases. We found that severe atrophy was predominant in patients with a BMI18 kg/m2.Celiac disease has an increasing prevalence and can be diagnosed at any age. Histology samples were indicative of different stages of villous atrophy. The disease prevalence is significantly higher among women. There was no statistically significant correlation between Marsh classification and BMI values. |
| Databáze: | OpenAIRE |
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