Xanthoceraside attenuates amyloid β peptide
| Autor: | Yue, Qi, Xue-Fei, Ji, Tian-Yan, Chi, Peng, Liu, Ge, Jin, Qian, Xu, Qing, Jiao, Li-Hua, Wang, Li-Bo, Zou |
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| Rok vydání: | 2017 |
| Předmět: |
Inflammation
Male Memory Disorders Mice Inbred ICR Amyloid beta-Peptides Dose-Response Relationship Drug Interleukin-6 NF-kappa B Nitric Oxide Synthase Type II Saponins Hippocampus Gene Expression Regulation Enzymologic Peptide Fragments Toll-Like Receptor 2 Triterpenes Mice Cognition Cyclooxygenase 2 Astrocytes Animals Interleukin-4 Microglia Mitogen-Activated Protein Kinases Maze Learning |
| Zdroj: | European journal of pharmacology. 820 |
| ISSN: | 1879-0712 |
| Popis: | Xanthoceraside, a novel triterpenoid saponin extracted from the husks of Xanthoceras sorbifolia Bunge, has neuroprotective effects in vivo and anti-inflammatory properties in vitro. However, the exact mechanism of xanthoceraside on anti-amyloid beta (Aβ)-induced neuroinflammatory responses has not been elucidated. Therefore, we used intracerebroventricular injection of amyloid |
| Databáze: | OpenAIRE |
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