| Autor: |
Guan-Hsun, Wang, Ai-Yu, Chuang, Yi-Chen, Lai, Hsin-I, Chen, Shu-Wei, Hsueh, Ya-Chin, Yang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
British journal of pharmacologyREFERENCES. 179(14) |
| ISSN: |
1476-5381 |
| Popis: |
Anticonvulsants targeting KMechanisms underlying epileptogenesis with A-channel inhibition and antiepileptic actions of A-channel activation were investigated with electrophysiological, pharmacological, optogenetic, and behavioral approaches.Pre-synaptic KTrans-synaptic voltage-dependent A-channels serve as a biophysical-biochemical transducer responsible for a novel form of synaptic plasticity. Such a network-level switch into and out of the oscillatory mode may underlie a wide scope of telencephalic information processing or, at its extreme, epileptic seizures. A-channels thus constitute a potential target of antiepileptic therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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