Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients
| Autor: | Nigel J P, Beasley, Russell, Leek, Mohammed, Alam, Helen, Turley, Graham J, Cox, Kevin, Gatter, Peter, Millard, Sue, Fuggle, Adrian L, Harris |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Aged 80 and over Adolescent L-Lactate Dehydrogenase Middle Aged Hypoxia-Inducible Factor 1 alpha Subunit Immunohistochemistry Disease-Free Survival Survival Rate Necrosis Treatment Outcome Head and Neck Neoplasms Basic Helix-Loop-Helix Transcription Factors Carcinoma Squamous Cell Trans-Activators Humans Aged HeLa Cells Transcription Factors |
| Zdroj: | Cancer research. 62(9) |
| ISSN: | 0008-5472 |
| Popis: | Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear transcription factors that regulate the cellular response to hypoxia and are important for solid tumor growth and survival. Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013). On immunostaining, HIF-1alpha and HIF-2alpha expression were localized to tumor nuclei; HIF-2alpha expression was also seen in tumor-associated macrophages. Expression of HIF-1alpha in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027). |
| Databáze: | OpenAIRE |
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