Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation

Autor:	M, Seiberg, S, Wisniewski, G, Cauwenbergh, S S, Shapiro
Rok vydání:	1997
Předmět:	Mice Inbred C57BL Mice Serine Endopeptidases Animals Cathepsin A Gene Expression Apoptosis Female Trypsin Carboxypeptidases Hair Color Hair Follicle Peptide Hydrolases
Zdroj:	Developmental dynamics : an official publication of the American Association of Anatomists. 208(4)
ISSN:	1058-8388
Popis:	Programmed cell death is a controlled process that leads to the elimination of single cells via apoptosis. Programmed cell death is fundamental to development, morphogenesis, and homeostasis. Proteases play a major role in the death process. We have previously shown that a serine protease, secreted by a keratinocyte cell line, can induce apoptosis in numerous cell lines. Here we show that serine proteases can induce cell death in vivo as well. Using a synchronized hair growth mouse model, we show that topical trypsin treatment following depilation induces cell death at the follicular papilla. This results in delaying hair growth and pigmentation. We speculate that trypsin might affect a receptor-mediated signaling pathway that leads to follicular papilla cell death.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::802f55b9e3cc35e598eb23c34eb5e286 https://pubmed.ncbi.nlm.nih.gov/9097027 Zobrazit plný text záznamu Plný text