[Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on antioxidative enzymatic activity]

Autor:	Jan, Kowalski, Lucjan, Pawlicki, Joanna, Grycewicz, Jan, Błaszczyk, Robert, Irzmańiski, Tomasz, Ceglińiski, Edward, Kowalczyk, Beata, Liban-Gałka
Rok vydání:	2005
Předmět:	Adult Male Erythrocytes Indoles Coronary Artery Disease Middle Aged Antioxidants Fatty Acids Monounsaturated Primary Prevention Treatment Outcome Heptanoic Acids Atorvastatin Humans Female Pyrroles Hydroxymethylglutaryl-CoA Reductase Inhibitors Fluvastatin
Zdroj:	Wiadomosci lekarskie (Warsaw, Poland : 1960). 58(5-6)
ISSN:	0043-5147
Popis:	The effect of atorvastatin and fluvastatin on antioxidative enzymatic activity was studied in CHD risk patients. The study comprised 35 patients (20 men and 15 women) aged 35-47 years, who were allotted into two groups: I--18 patients were administered fluvastatin (Lescol) in a dose of 40 mg once daily at bed time for 6 weeks and II--17 patients were administered atorvastatin (Sortis) in a dose of 10 mg once daily at bed time for 6 weeks. The control group consisted of 12 clinically healthy subjects, aged 34-42 years. SOD-1, GSH-Px and CAT activity in erythrocytes was measured. Greater increase of low erythrocyte antioxidative enzymatic activity was observed in atorvastatin than in fluvastatin group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8021917a93544fb4735a26cf8815bbbf https://pubmed.ncbi.nlm.nih.gov/16238116 Zobrazit plný text záznamu