Glycosaminoglycan from
| Autor: | Yunmei, Chen, Yuanhong, Wang, Shuang, Yang, Mingming, Yu, Tingfu, Jiang, Zhihua, Lv |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male AMPK Apostichopus japonicus glucose metabolism Akt Gluconeogenesis AMP-Activated Protein Kinases Article Mice Inbred C57BL Mice Glucose Liver Stichopus Glucose-6-Phosphatase Insulin Receptor Substrate Proteins glycosaminoglycan Animals Cytokines Insulin Insulin Resistance Phosphorylation Proto-Oncogene Proteins c-akt Glycosaminoglycans Signal Transduction |
| Zdroj: | Marine Drugs |
| ISSN: | 1660-3397 |
| Popis: | Holothurian glycosaminoglycan isolated from Apostichopus japonicus (named AHG) can suppress hepatic glucose production in insulin resistant hepatocytes, but its effects on glucose metabolism in vivo are unknown. The present study was conducted to investigate the effects of AHG on hyperglycemia in the liver of insulin resistant mice induced by a high-fat diet (HFD) for 12 weeks. The results demonstrated that AHG supplementation apparently reduced body weight, blood glucose level, and serum insulin content in a dose-dependent manner in HFD-fed mice. The protein levels and gene expression of gluconeogenesis rate-limiting enzymes G6Pase and PEPCK were remarkedly suppressed in the insulin resistant liver. In addition, although the total expression of IRS1, Akt, and AMPK in the insulin resistant liver was not affected by AHG supplementation, the phosphorylation of IRS1, Akt, and AMPK were clearly elevated by AHG treatment. These results suggest that AHG could be a promising natural marine product for the development of an antihyperglycemic agent. |
| Databáze: | OpenAIRE |
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