| Autor: |
Enrico, Ammirati, Francesco, Moroni, Marco, Magnoni, Elena, Busnardo, Simona, Di Terlizzi, Chiara, Villa, Federico, Sizzano, Isabella, Scotti, Alessio, Palini, Luca, Presotto, Valentino, Bettinardi, Pietro, Spagnolo, Francesca, Besana, Luigi, Gianolli, Ornella E, Rimoldi, Paolo G, Camici |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
International Journal of Cardiology. Heart & Vasculature |
| ISSN: |
2352-9067 |
| Popis: |
Background We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11C-PK11195. Methods and results In 9 patients with carotid plaques we performed 11C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for 11C-PK11195 was negatively correlated with concentrations of total monocytes (r = −0.58, p = 0.05) and CD14++CD16−HLA-DR+ classical subset (r = −0.82, p = 0.005). These correlations hold true also in relation to plaque target to background ratio. No correlation was observed between plaque SUV and CD3+T lymphocytes, CD4+T lymphocytes nor with activated CD3+CD4+T cells expressing HLA-DR. Conclusions We first demonstrated a reduction in the absolute concentration of monocytes and particularly in classical monocytes expressing HLA-DR in the presence of an increased uptake of 11C-PK11195 in carotid plaques. The present work, despite being a pilot study comprising only a small number of subjects provides new insights in the search for specific cellular biomarkers with potential diagnostic and prognostic value in patients with a known carotid plaque. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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