| Autor: |
C O, Tacket, G, Losonsky, J P, Nataro, S J, Cryz, R, Edelman, J B, Kaper, M M, Levine |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
The Journal of infectious diseases. 166(4) |
| ISSN: |
0022-1899 |
| Popis: |
CVD 103-HgR is a live oral cholera vaccine that, in phase I and II studies to date, has been well tolerated and immunogenic. In challenge studies of US volunteers conducted 4-5 weeks after vaccination, CVD 103-HgR provided significant protection against experimental cholera due to classical and El Tor Vibrio cholerae O1. To determine the onset and duration of protection, two volunteer challenge studies were conducted: the first, 6 months after vaccination and the second, 8 days after vaccination. In both studies, CVD 103-HgR was 100% protective against diarrhea and significantly reduced the rate of shedding of vibrios after challenge with V. cholerae classical Inaba strain 569B, the virulent parent strain of CVD 103-HgR. Previously vaccinated subjects were less likely than naive controls to develop rises in titer of vibriocidal antibodies after challenge (P = .002), and the mean peak titer of vibriocidal antibodies was less than among controls. CVD 103-HgR can provide homologous protective immunity as soon as 8 days after vaccination and protection can persist for at least 6 months. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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