| Autor: |
D G, Shulman, L L, Lothringer, J M, Rubin, R B, Briggs, J, Howes, G D, Novack, K, Hart |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Ophthalmology. 106(2) |
| ISSN: |
0161-6420 |
| Popis: |
To evaluate the effects of loteprednol etabonate (LE) 0.2% in reducing the signs and symptoms of seasonal allergic conjunctivitis.Randomized, double-masked, placebo-controlled, parallel group multicenter study of 6 weeks duration.A total of 135 patients with signs and symptoms of seasonal allergic conjunctivitis participated.All patients received either LE 0.2% or placebo (vehicle) four times a day in both eyes for 42 days.Bulbar conjunctival injection (primary sign) and itching (primary symptom) over the first 2 weeks of treatment was measured.A reduction in severity was seen in both LE and placebo groups for bulbar conjunctival injection (1.5 vs. 1.0 units on a 0-3 scale) and itching (3.4 vs. 3.0 units on a 0-4 scale) over the first 2 weeks. The treatment effect by these measures was -0.5 and -0.4 units in favor of LE (Por = 0.008). Resolution (i.e., the proportion of patients with signs or symptoms no longer present) at day 14 strongly favored LE-treated patients (36% and 15%; 58% and 38%, for injection and itching, respectively). Both treatments were well tolerated. One patient in each treatment group (1 of 67 and 1 of 68, respectively) had an elevation of intraocular pressure of 10 mmHg or greater during the 6 weeks of treatment.Loteprednol etabonate 0.2% was more effective than placebo in the treatment of seasonal allergic conjunctivitis. Loteprednol etabonate 0.2% had a safety profile comparable to placebo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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