O/SEA/Mya-98 lineage foot-and-mouth disease virus was responsible for an extensive epidemic that occurred in late 2018 in Vietnam

Autor:	Nguyen, Van Diep, Trinh Thi Bich, Ngoc, Le Quoc, Hoa, Bui Thi To, Nga, BoKyo, Kang, Jinsik, Oh, Nguyen Thi, Lan, Van Phan, Le
Rok vydání:	2019
Předmět:	Swine Diseases Base Sequence Vietnam Foot-and-Mouth Disease Virus Reverse Transcriptase Polymerase Chain Reaction Swine Foot-and-Mouth Disease Animals RNA Viral Capsid Proteins Amino Acid Sequence Sequence Analysis DNA Disease Outbreaks
Zdroj:	Archives of virology. 165(11)
ISSN:	1432-8798
Popis:	Since late 2018, foot-and-mouth disease (FMD) has reemerged and rapidly swept through pig farms in North and Central Vietnam, despite widespread use of commercial FMD vaccines. To investigate the FMD virus (FMDV) strains responsible for the current epidemics, 40 FMDV samples were collected from 17 provinces during November-December 2018, and the VP1 coding genes were sequenced and analyzed. Phylogenetic analysis and sequence comparisons revealed that all of the reemerging Vietnamese FMDVs belonged to the Mya-98 lineage of the O/Southeast Asia topotype (O/SEA/Mya-98) and shared high nucleotide (99.06-100% identity) and amino acid (97.65-100% identity) sequence similarity with each other. The study results suggested that the reemerging FMDVs originated from local Vietnamese strains. Field viruses had different amino acids in the antigenic sites of VP1 when compared to the strains used in the vaccines. The present study provides an important basis for vaccine selection in the battle against FMD in Vietnam.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7fb2de156d7ce0c27f8eab3f223c6d1b https://pubmed.ncbi.nlm.nih.gov/32772250 Zobrazit plný text záznamu Full text from SpringerLink