Central motor drive is increased during voluntary muscle contractions in multiple sclerosis

Autor:	A V, Ng, R G, Miller, J A, Kent-Braun
Rok vydání:	1997
Předmět:	Adult Central Nervous System Male Motor Neurons Volition Multiple Sclerosis Electromyography Reference Values Humans Female Middle Aged Severity of Illness Index Muscle Contraction
Zdroj:	Musclenerve. 20(10)
ISSN:	0148-639X
Popis:	To test the hypothesis that central motor drive is increased during voluntary contractions in multiple sclerosis (MS) patients, we recorded the surface electromyogram (EMG) and force from the tibialis anterior muscle during isometric dorsiflexion in 14 MS and 18 control subjects. Measurements were obtained during contractions at 10-100% of maximal voluntary contraction (MVC), incremented by 10% MVC. Integrated EMG (% maximum) was elevated in MS compared to controls from 10 to 70% MVC (pairwise, P0.05; main effect, P=0.001). MS severity (Expanded Disability Status Scale) was highly correlated to the individual slopes of the EMG/force relationship (r=-0.87, P0.001). We conclude that central motor drive in MS is increased throughout a large range of submaximal contractions and that this increase is associated with overall disease severity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7f5090c2759a29d146fc28c5641426ce https://pubmed.ncbi.nlm.nih.gov/9324075 Zobrazit plný text záznamu Plný text