Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study

Autor:	Leif, Nelin, John P, Kinsella, Sherry E, Courtney, Eugenia K, Pallotto, Eva, Tarau, Jim L, Potenziano
Rok vydání:	2021
Předmět:	Hypertension Pulmonary Administration Inhalation Infant Newborn Humans Registries Hypoxia Nitric Oxide Respiratory Insufficiency
Zdroj:	Journal of perinatology : official journal of the California Perinatal Association. 42(1)
ISSN:	1476-5543
Popis:	To evaluate inhaled nitric oxide (iNO) in preterm (PT) vs term/near-term (TNT) neonates with hypoxic respiratory failure (HRF) and pulmonary hypertension (PH) in an observational registry (PaTTerN).Non-inferiority study comparing PT neonates of GA ≥ 27 to34 weeks vs TNT neonates of GA ≥ 34 to ≤40 weeks with HRF associated with PH, who received iNO for 24-96 h during the first 0-7 days after birth. Primary endpoint: Achieving ≥25% decrease in oxygenation index/surrogate oxygenation index during iNO treatment.Of 140 neonates (PT, n = 55; TNT, n = 85), the primary endpoint was achieved in 50 (90.9%) PT vs 75 (88.2%) TNT neonates (difference [95% CI]: 0.027 [-0.033, 0.087]); PT neonates achieved non-inferiority interval, and the study was stopped early based on prespecified criteria.Use of iNO for improving oxygenation in PT neonates with HRF associated with PH is at least as effective as in TNT neonates.#NCT03132428, registered April 27, 2017.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7f243eed3b5d6b0a38f18633053e28d6 https://pubmed.ncbi.nlm.nih.gov/34711938 Zobrazit plný text záznamu Full text from SpringerLink