| Autor: |
A, Di Costanzo-Mata, J, Jiang, S, Lindner, C, Zhang, E, Charbon, M, Wolf, A, Kalyanov |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Advances in experimental medicine and biology. 1269 |
| ISSN: |
0065-2598 |
| Popis: |
In preterm infants, there is a risk of life-lasting impairments due to hemorrhagic/ischemic lesions. Our time-domain (TD) near-infrared optical tomography (NIROT) system "Pioneer" aims at detecting both disorders with high spatial resolution. Successfully tested on phantoms, "Pioneer" entered the phase of improvements and enhancements. The current probe (A-probe) was adapted for an optoacoustics instrument. A new probe (B-probe) optimized for TD measurements is required. Our aim is to determine the optimal arrangement of light sources in the B-probe to increase the sensitivity and the resolution of Pioneer and to improve the ability of the system to detect both ischemia and hemorrhage. To do this, we simulated TD-NIROT signals in NIRFAST, a MATLAB-based package used to model near-infrared light propagation through tissue. We used 16 × 16 detector array, with ~2.2 mm distance between the detectors. Light sources were arranged around the field of view (FoV). We performed forward simulations of light propagation through a "homogeneous case" (HC) tissue (μ' |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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