| Autor: |
A N, Iniushkin, E M, Iniushkina, N A, Merkulova |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 94(1) |
| ISSN: |
0869-8139 |
| Popis: |
Regulatory polypeptide leptin, apart from its well-known hypothalamic effects, stimulates ventilation. The present study on anaesthetised rats was undertaken to elucidate the respiratory effects of 10(-10)-10(-4) M leptin microinjected into the solitary tract nucleus, containing a high concentration of leptin receptors. Injections of 10(-8)-10(-4) M leptin induced dose-dependent increase in ventilation, tidal volume and electric activity of inspiratory muscles; 10(-6) M leptin additionally induced a short-term increase in respiratory frequency and a shortening of both inspiratory and expiratory duration. The respiratory responses to leptin is also characterised by appearance of sighs: deep and prolonged inspirations associated with an augmented burst in the activity of the inspiratory muscles and prolonged post-sigh inter-burst interval. The results taken together with evidence of high concentration of specific leptin ObRb-receptor in the solitary tract nucleus suggest involvement of endogenous leptin in the control of breathing via dorsal structures of the respiratory center. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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