Antibacterial and antibiofilm activities of ceragenins against

Autor: Damla, Damar-Çelik, Emel, Mataracı-Kara, Paul B, Savage, Berna, Özbek-Çelik
Rok vydání: 2020
Předmět:
Zdroj: Journal of chemotherapy (Florence, Italy). 33(4)
ISSN: 1973-9478
Popis: Achromobacter species, which are recognized as emerging pathogens isolated from patients with cystic fibrosis, are capable of forming biofilm in the respiratory tract in patients and innate multidrug resistance to antimicrobials. CSAs are cationic salt derivatives that mimic the activity of antimicrobial peptides and exhibit antimicrobial activity against bacteria. In this study, the in vitro activities of various ceragenins against Achromobacter-species biofilms were investigated comparatively with a conventional antibiotic (meropenem). Biofilm-formation inhibition and biofilm-adhesion inhibition were investigated on five strong biofilm-producing strains. The lowest MIC
Databáze: OpenAIRE