| Autor: |
R M, Hopp, N, Ransom, S G, Hilsenbeck, D S, Papermaster, J J, Windle |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Molecular vision. 4 |
| ISSN: |
1090-0535 |
| Popis: |
To determine if p53 mediates apoptosis in photoreceptors of retinal degeneration, rd1, mice.The rd1/rd1 mice were interbred with p53 null mice to generate p53-/- rd1/rd1 and p53+/+ rd1/rd1 mice. Rates of loss and incidence of apoptosis in rod photoreceptors were analyzed at appropriate ages (postnatal days 12, 14 and 16).The extent and kinetics of photoreceptor cell loss in rd1 mice were nearly indistinguishable in the p53+/+ and p53 null mice.Photoreceptor cell apoptosis in the rd1 mouse model occurs by a predominantly p53-independent molecular pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
