Chiral amine enantiomeric excess determination using self-assembled octahedral Fe(II)-imine complexes

Autor:	Justin M, Dragna, Alexandra M, Gade, Lee, Tran, Vince M, Lynch, Eric V, Anslyn
Rok vydání:	2014
Předmět:	organic chemicals Circular Dichroism Iron Calibration polycyclic compounds Organometallic Compounds heterocyclic compounds Stereoisomerism Imines Amines Article
Zdroj:	Chirality. 27(4)
ISSN:	1520-636X
Popis:	A receptor assembly composed of iron(II) triflate and pyridine-2,6-dicarbaldehyde is used to determine the enantiomeric excess of alpha-chiral primary amines using circular dichroism spectroscopy. The alpha chiral amines condense with the dialdehyde to form a diimine, which forms a 2:1 octahedral complex with iron(II). The enantiomeric excess values of unknown concentrations of alpha-chiral amines were determined by constructing calibration curves for each amine and then measuring the ellipticity at 600nm. This improves our previously reported assay for enantiomeric excess determination of chiral primary amines by further increasing the wavelength at which CD is measured and reducing the absolute error of the assay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7e80ed3a6b2c88f11f460d8818aab9c0 https://pubmed.ncbi.nlm.nih.gov/25664936 Zobrazit plný text záznamu Plný text