| Autor: |
T, Haruta, S, Kuroki, K, Ohkura, H, Nikami, T, Nishio, Y, Kobayashi |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
The Japanese journal of antibiotics. 47(12) |
| ISSN: |
0368-2781 |
| Popis: |
The efficacy and the safety of biapenem (L-627), a new carbapenem antibiotic, against infections in pediatrics were studied. The obtained results are summarized as follows. 1. L-627 at dose levels of 5.4 mg/kg to 12.4 mg/kg (daily doses of 16.2 mg/kg to 37.2 mg/kg) was administered by intravenous drip infusion 3 times daily for 5 to 7 days to 2 cases of pneumonia, 3 cases of skin and soft-tissue infections and 1 case of urinary tract infection for a total of 6 cases. As results, all the cases showed good or better responses including 4 excellent and 2 good results. Bacteriological efficacies in all of the 3 eligible cases were assessed as "eradicated". 2. As for the safety, a decrease in the WBC count and slight elevation of GOT and GPT were observed in 1 case as abnormal changes in the laboratory tests results, only incidence of side effect observed was the eruption in 1 case. 3. The results above indicate that L-627 is useful for the treatment of general infections in pediatrics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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