| Autor: |
Z, Modr, K, Dvorácek, I, Janků, V, Krebs |
| Jazyk: |
němčina |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
Infection. 10 |
| ISSN: |
0300-8126 |
| Popis: |
We studied the pharmacokinetics of azlocillin in 11 healthy persons following an i. v. infusion of 5 g over 30 minutes. The azlocillin concentrations in serum and urine were measured microbiologically. The serum concentrations averaged 530.5 (+/- 79.2) mg/l at the end of the infusion and 9.4 (+/- 4.3) mg/l six hours later. 73.8% of the dose was excreted in the urine during a period of six hours. The serum concentrations of azlocillin were analysed using a two-compartment model, and the pharmacokinetic constants were calculated by a computer. The average biological half-life (beta-phase) of azlocillin was 70.2 (+/- 7.8) min, the plasma clearance was 1.869 (+/- 0.284) ml/sec and the distribution volume (Vd area) was 11.34 (+/- 2.05) l, i. e. 0.17 l/kg. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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