| Autor: |
W A, Ritschel, G J, Alcorn, W H, Streng, M A, Zoglio |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Methods and findings in experimental and clinical pharmacology. 5(1) |
| ISSN: |
0379-0355 |
| Popis: |
Cimetidine forms a complex with theophylline in vitro in both pH 7.4 buffer and human plasma. The increase in the amount of theophylline in solution is about 20% in the buffer system and about 36% in plasma. It is hypothesized that this complex formation may contribute to and be part of the mechanism of the clinically observed decreased theophylline clearance in man in presence of cimetidine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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