Corrective effect of clotrimazole and beta-ionol during exposure to thiophenol

Autor:	V A, Dadali, N E, Golovanova, R N, Pavlova, N E, Dzhangulova, V E, Vinogradova
Rok vydání:	2000
Předmět:	Male Free Radicals Terpenes Erythrocyte Membrane Butylated Hydroxytoluene Catalase Antioxidants Rats Hemoglobins Glutathione Reductase Cytochrome P-450 Enzyme System Phenols Enzyme Induction Animals Sulfhydryl Compounds Clotrimazole Norisoprenoids Glutathione Transferase
Zdroj:	Bulletin of experimental biology and medicine. 130(11)
ISSN:	0007-4888
Popis:	Toxic effect of thiophenol on rats can be prevented by injection of antioxidant beta-ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7dbdbdd73be18401cad813b8cc7c328f https://pubmed.ncbi.nlm.nih.gov/11182824 Zobrazit plný text záznamu Full text from SpringerLink