| Autor: |
Javian C, Malcolm, Nadia, Falzone, Jennifer E, Gains, Matthew D, Aldridge, David, Mirando, Boon Q, Lee, Mark N, Gaze, Katherine A, Vallis |
| Rok vydání: |
2021 |
| Zdroj: |
EJNMMI physics. 9(1) |
| ISSN: |
2197-7364 |
| Popis: |
Recent reports personalizing the administered activity (AA) of each cycle of peptide receptor radionuclide therapy based on the predicted absorbed dose (AD) to the kidneys (dose-limiting organ) have been promising. Assuming identical renal pharmacokinetics for each cycle is pragmatic, however it may lead to over- or under-estimation of the optimal AA. Here, we investigate the influence that earlier cycles of [A simulation study, based on dosimetry data from six children with NBL who received four-cycles of [The median tumour AD per cycle was found to decrease from 15.6 Gy (range 8.12-26.4) in cycle 1 to 11.4 Gy (range 9.67-28.8), 11.3 Gy (range 2.73-32.9) and 4.3 Gy (range 0.72-20.1) in cycles 2, 3 and 4, respectively. By the fourth cycle, the median of the ratios of the delivered AD (ADThis study demonstrates variability in Gy/GBq and tumour AD per cycle in children receiving four administrations of [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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