A cholesterol analog stabilizes the human β
Autor: | Tetiana, Serdiuk, Moutusi, Manna, Cheng, Zhang, Stefania A, Mari, Waldemar, Kulig, Kristyna, Pluhackova, Brian K, Kobilka, Ilpo, Vattulainen, Daniel J, Müller |
---|---|
Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Science signaling. 15(737) |
ISSN: | 1937-9145 |
Popis: | In cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β |
Databáze: | OpenAIRE |
Externí odkaz: |