A cholesterol analog stabilizes the human β

Autor: Tetiana, Serdiuk, Moutusi, Manna, Cheng, Zhang, Stefania A, Mari, Waldemar, Kulig, Kristyna, Pluhackova, Brian K, Kobilka, Ilpo, Vattulainen, Daniel J, Müller
Rok vydání: 2022
Předmět:
Zdroj: Science signaling. 15(737)
ISSN: 1937-9145
Popis: In cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β
Databáze: OpenAIRE