G9a controls placental vascular maturation by activating the Notch Pathway
| Autor: | Lijun, Chi, Abdalla, Ahmed, Anna R, Roy, Sandra, Vuong, Lindsay S, Cahill, Laura, Caporiccio, John G, Sled, Isabella, Caniggia, Michael D, Wilson, Paul, Delgado-Olguin |
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| Rok vydání: | 2017 |
| Předmět: |
Fetal Growth Retardation
Receptors Notch Transcription Genetic Organogenesis Placenta Stem Cells Down-Regulation Embryonic Development Endothelial Cells Gene Expression Regulation Developmental Histone-Lysine N-Methyltransferase Embryo Mammalian Trophoblasts Mice Cell Movement Pregnancy Histocompatibility Antigens Immunoglobulin J Recombination Signal Sequence-Binding Protein Animals Humans Female Cell Proliferation Signal Transduction |
| Zdroj: | Development (Cambridge, England). 144(11) |
| ISSN: | 1477-9129 |
| Popis: | Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation, during which blood vessels elongate. However, the cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase G9a, also known as Ehmt2, activates the Notch pathway to promote placental vascular maturation. Placental vasculature from embryos with G9a-deficient endothelial progenitor cells failed to expand owing to decreased endothelial cell proliferation and increased trophoblast proliferation. Moreover, G9a deficiency altered the transcriptional switch initiating placental maturation and caused downregulation of Notch pathway effectors including |
| Databáze: | OpenAIRE |
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