Long-term effects of combined immunosuppressive treatment on myasthenic crisis
| Autor: | C, Rózsa, A, Mikor, K, Kasa, Z, Illes, S, Komoly |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Clinical Trials as Topic Chi-Square Distribution Prednisolone Middle Aged Severity of Illness Index Statistics Nonparametric Case-Control Studies Azathioprine Myasthenia Gravis Humans Drug Therapy Combination Female Longitudinal Studies Glucocorticoids Immunosuppressive Agents Aged Retrospective Studies |
| Zdroj: | European journal of neurology. 16(7) |
| ISSN: | 1468-1331 |
| Popis: | We studied the long-term crisis-preventing effect of combined prednisolone-azathioprine (PR-AZA) treatment in myasthenia gravis (MG).Case-control study with a median follow-up of 64 months in the treated group, and 80 months in the non-treated group. Sixty-nine patients with episodes of myasthenic crisis (MC) were treated and followed prospectively in 1990-2004. Twenty-seven patients had MC between 1990 and 1996, and were not treated with immunosuppressants on long-term. Long-term PR-AZA treatment was introduced in another 42 patients, who developed MC in 1997-2004. The difference in the frequency of repeated MCs between the treated and the non-treated group during long-term follow-up was investigated. As secondary end-points, we analyzed the number of admittances to the ICU; the number of mechanical ventilation episodes; the duration of ICU treatment; the characteristics of the applied treatment; and the functional outcome of the patients 1 month after the onset of the crisis.Recurrent MCs occurred in 74% of the non-treated and 19% of the treated group (P0.001). The number of ICU admissions (P = 0.005) and mechanical ventilation events (P = 0.002) were also reduced. The highly significant MC preventing effect of PR-AZA was evident after 6 months.After the initial 6 months of therapy, PR-AZA is effective in preventing MC. |
| Databáze: | OpenAIRE |
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