Persistent tracheostomy after primary chemoradiation for advanced laryngeal or hypopharyngeal cancer
| Autor: | Paul A, Tennant, Elizabeth, Cash, Jeffrey M, Bumpous, Kevin L, Potts |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Aged 80 and over Male Hypopharyngeal Neoplasms Time Factors Databases Factual Chemoradiotherapy Kaplan-Meier Estimate Middle Aged Long-Term Care Risk Assessment Survival Analysis Disease-Free Survival Tracheostomy Quality of Life Humans Female Neoplasm Invasiveness Laryngeal Neoplasms Organ Sparing Treatments Aged Follow-Up Studies Neoplasm Staging Retrospective Studies |
| Zdroj: | Headneck. 36(11) |
| ISSN: | 1097-0347 |
| Popis: | Despite the demonstrated survival equivalence between chemoradiation and ablative surgery as primary treatment for advanced laryngeal and hypopharyngeal cancers, a subset of patients who undergo organ-preservation therapy have persistent tracheostomy requirement after completion of treatment.Patients who received primary chemoradiation for advanced laryngeal or hypopharyngeal cancer in a 3-year interval were identified. Rate of persistent posttreatment tracheostomy requirement was evaluated. The 12-month overall mortality rate was compared between patients who did and did not receive a tracheostomy before treatment.In 60 patients identified for this study, T3/T4 status and hemilarynx fixation at the time of presentation were associated with persistent tracheostomy requirement 6 and 12 months posttreatment (p = .022; p.001; and p = .032; p = .0495, respectively). Twelve-month mortality was higher in T3/T4 patients who received pretreatment tracheostomy (p = .034).Patients with advanced laryngeal or hypopharyngeal cancer who require tracheostomy before treatment have low rates of decannulation and higher short-term mortality than those who do not require tracheostomy before organ-preservation therapy. |
| Databáze: | OpenAIRE |
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