Evaluation of the Relationship Between Ischemia-Modified Albumin Levels and Thyroid Hormone Levels
| Autor: | Mufide, Oncel, Aysel, Kıyıcı, Serife, Onen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Aged 80 and over Male endocrine system Thyroid Hormones endocrine system diseases Adolescent Serum Albumin Human Original Articles Middle Aged Prognosis Hyperthyroidism Oxidative Stress Young Adult Hypothyroidism Humans Female hormones hormone substitutes and hormone antagonists Biomarkers Serum Albumin Aged Follow-Up Studies |
| Zdroj: | Journal of clinical laboratory analysis. 29(6) |
| ISSN: | 1098-2825 |
| Popis: | BACKGROUND: A novel ischemia marker named ischemia modified albumin was previously considered as an early marker of myocardial ischemia, however due to recent reports, its contribution was demonstrated in different pathologies such as oxidative stress, diabetes, stroke and cancer. We aimed to investigate the relation between oxidative stress and thyroid dysfunctions determining IMA levels since IMA is closely related with increased oxidative stress. METHODS: A total of 88 individuals were participated in this study: 34 cases in hypothyroid, 27 cases in hyperthyroid and 27 cases in euthyroid group. Ischemia‐modified albumin levels were measured by albumin cobalt binding test and thyroid hormone levels were determined with electrochemiluminescent method. RESULTS: Ischemia modified albumin levels were significantly decreased in hypothyroid group compared to hyperthyroid and euthyroid groups (p < 0.001). In hyperthyroid individuals ischemia modified albumin levels were higher compared to euthyroid ones (p < 0.001). Ischemia modified albumin was negatively correlated with TSH levels (r = −0.473, p < 0.001), and positively correlated with FT4 and FT3 levels (r = 0.496, p < 0.001 and r = 0.275, p = 0.010, respectively). CONCLUSION: We suggest that albumin adjusted IMA levels are significantly lower in hypothyroid group than hyperthyroid and euthyroid groups. |
| Databáze: | OpenAIRE |
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