| Autor: |
Monique H M, Derikx, B W Marcel, Spanier, Jan Maarten, Vrolijk |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Nederlands tijdschrift voor geneeskunde. 155(33) |
| ISSN: |
1876-8784 |
| Popis: |
The Hepatitis delta virus (HDV) is a defect RNA virus that requires the presence of the hepatitis B virus (HBV) for cellular infection. Worldwide, 350 million people are infected with HBV; 5% of these are superinfected with HDV. A chronic superinfection with HDV has a higher morbidity and mortality rate. It is clinically difficult to differentiate between an HBV and an HDV infection. Diagnosis is made via detection of HDV antibodies and HDV-RNA using PCR techniques. The only treatment option is peginterferon-alpha 180 μg subcutaneously once a week for 48 weeks.A 37-year-old man with a Syrian background and a chronic HBV infection presented with high levels of ALT indicating severe hepatitis. The level of detected HBV-DNA-particles was low, however, indicating that the HBV infection alone could not be responsible for the inflammation. Further investigations revealed a superinfection with HDV. The patient was successfully treated with peginterferon-alpha.Severe hepatitis (high ALT level) in combination with a low HBV-DNA-particle level can indicate a HDV superinfection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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