| Autor: |
I H, Pastan |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Cancer detection and prevention. 17(2) |
| ISSN: |
0361-090X |
| Popis: |
We have developed new agents for the treatment of cancer by genetically modifying Pseudomonas exotoxin. We have deleted the cell-binding region of Pseudomonas exotoxin and replaced it with various growth factors or the combining regions of antibodies in a single chain form. These new recombinant molecules are called recombinant toxins. Several different types of recombinant toxins have been produced. B3(Fv)-PE38KDEL is a recombinant toxin that kills many different adenocarcinomas and epidermoid carcinomas. The molecule is now undergoing preclinical development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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